Molecular investigation of mechanisms considered to cause preterm premature membrane rupture

Purpose: The aim of this study was to investigate the mRNA expression level p16, CDK4, CDK6, Cyclin D, RB1, and E2F genes in preterm premature rupture membrane (PPROM) cases their roles etiopathogenesis PPROM. 
 Materials Methods: Twenty-one pregnancies with PPROM before 34th gestational weeks (study group) were compared twenty no complication, who gave birth after 37th gestational-week (control group). Both groups chorioamniotic membranes for cyclin RB1 genes.
 Results: levels RB1and decreased group control at a statistically significant level.
 Conclusion: Our findings have shown that oxidative stress may not act on p16 pathway these cases. In order understand molecular mechanism PPROM, biomarkers aging should be evaluated together other pathways related future studies.